Kinome focused CRISPR-Cas9 screens in African ancestry patient-derived breast cancer organoids identify essential kinases and synergy of EGFR and FGFR1 inhibition

Abstract excerpt

<title>Abstract</title> <p>Precision medicine approaches to cancer treatment aim to exploit genomic alterations that are specific to individual patients to tailor therapy strategies. These alterations are usually revealed via next generation sequencing of the tumor tissue. Yet, it is clear that some targetable genes and pathways are essential for tumor cell viability even in the absence of direct genomic alterati...

Topics

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• Algorithms
• Cancer Genomics and Diagnostics
• CAR-T cell therapy research
• Computational Biology
• CRISPR and Genetic Engineering
• CRISPR-Associated Proteins
• CRISPR-Cas Systems
• Gene Expression Regulation, Neoplastic

Identifiers and source

Literature Corpus work

97587aaf-0eb1-5604-b86a-481db30e4bd6

DOI

10.21203/rs.3.rs-3857407/v1