Article
A tumour-derived organoid biobank maps cancer gene dependencies.
Nature - 1 Sept 2026
Herranz-Ors C, Bhosle S G, Beck A E, Gilbert J G R, Picco G, Espejo Valle-Inclan J, Muyas F, Valentini S, Andres A E, Ansari R, Barthorpe S, Battarbee G, Beaver C M, Brocklesby S, Cantwell J, Collins C A, Davis J, Dimitrova H G, Doran J, Efendi E, Evans K, Fekry M, Fowler T A, Garcia-Casado M, Griffiths J A T, Hall C, Hamer R, Hardy C, Hewitson Z, Hitch E, Holland L, Jackson D A, Joshi N, Kavasakali A, Letchford L, Lightfoot H B, Lingala H, Mali I, May K, Mironenko T, Morris J, Pacini C, Price S, Robert-Tissot G, Rogers H A, Smith J V, Smith K, Souster E, Spence W J, Thomas F, Vieira S F, Walker S, Alfonsin G, Bermingham H, Coles H, Ennis D P, Freeman A, Giannone G, Grehan N, Griffiths E A, Hall J, Lee S L, Leung E Y L, Loreno C, Millington C, Mirnezami A, Nutzinger B, Orzechowska K, Pinna C M A, Redmond A M, Roberts K, Roy S, Sanders D A, Taniere P, Vias M, Wanigasooriya K, Stratton M R, Staudt L M, McDermott U, Brenton J D, McNeish I A, Biankin A, Sansom O J, Cortes-Ciriano I, Underwood T J, Fitzgerald R C, Beggs A D, Francies H E, Garnett M J
Abstract excerpt
Cancer cell lines remain foundational for research and drug discovery, yet they incompletely capture tumour diversity, lack linked patient context, and have undergone adaptation to culture. Tumour organoids are three-dimensional cultures derived from patient tissue that offer a powerful complement to cell lines1. Here we derived and characterized 256 clinically annotated tumour organoids directly from colorectal,...
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