Kinome focused CRISPR-Cas9 screens in African ancestry patient-derived breast cancer organoids identifies essential kinases and synergy of EGFR and FGFR1 inhibition

Abstract excerpt

Precision medicine approaches to cancer treatment aim to exploit genomic alterations that are specific to individual patients to tailor therapy strategies. These alterations are usually revealed via next generation sequencing of the tumor tissue. Yet, it is clear that some targetable genes and pathways are essential for tumor cell viability even in the absence of direct genomic alterations. This is especially impo...

Topics

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• Algorithms
• Cancer Genomics and Diagnostics
• CAR-T cell therapy research
• Computational Biology
• CRISPR and Genetic Engineering
• CRISPR-Associated Proteins
• CRISPR-Cas Systems
• Gene Expression Regulation, Neoplastic

Identifiers and source

Literature Corpus work

cee2bc12-5a94-5325-a4aa-360776c935dd

DOI

10.1101/2023.12.11.570465