Article

Genome-wide mapping of oncogenic pathways and genetic modifiers of chemotherapy using a high-risk hepatoblastoma genetic model

2022-03-30

Abstract excerpt

<title>Abstract</title> <p>A lack of relevant genetic models and cell lines hampers our understanding of hepatoblastoma pathogenesis and the development of new therapies for this neoplasm. We report a liver-specific MYC-driven hepatoblastoma murine model that faithfully recapitulates the pathological features of mixed fetal and embryonal hepatoblastoma, with transcriptomics resembling the high-risk gene signature...

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Literature Corpus work: 04626705-d1da-5fe4-b5f9-ec12594950d0
DOI: 10.21203/rs.3.rs-1438842/v1

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