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A functional genetic toolbox for human tissue-derived organoids

6 Oct 2021

Abstract excerpt

Human organoid systems recapitulate key features of organs offering platforms for modelling developmental biology and disease. Tissue-derived organoids have been widely used to study the impact of extrinsic niche factors on stem cells. However, they are rarely used to study endogenous gene function due to the lack of efficient gene manipulation tools. Previously, we established a human foetal lung organoid system...

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PMID: 34612202
DOI: 10.7554/elife.67886

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