Article

AD-genes and Aging Increase Count and Size of Lipid Droplets, Accompanied by Accumulation of Neutral Lipids Across Compartments in Hippocampal Neurons.

2025-07-05

Abstract excerpt

Lipid homeostasis plays a crucial role in neuronal function, yet its dynamics during aging and neurodegenerative diseases remain poorly understood. Our study unveils critical age-related changes in lipid polarity and lipid droplet characteristics in hippocampal neurons from non-transgenic (NTg) mice and from an Alzheimer's disease-model (3xTg-AD). Using advanced spectral imaging and phasor analysis techniques, we...

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Literature Corpus work: c3697312-2654-5178-9123-46221fb49b68
DOI: 10.1101/2025.07.01.661999

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AD-genes and Aging Increase Count and Size of Lipid Droplets, Accompanied by Accumulation of Neutral Lipids Across Compartments in Hippocampal Neurons.DOI 10.1101/2025.07.01.661999Read

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