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Article

Cell-binding IgM in CSF is distinctive of multiple sclerosis and targets the iron transporter SCARA5

2023-10-02

Abstract excerpt

Intrathecal IgM production in multiple sclerosis (MS) is associated with a worse disease course. To investigate pathogenic relevance of autoreactive IgM in MS, CSF from two independent cohorts, including MS patients and controls, were screened for antibody binding to induced pluripotent stem cell-derived neurons and astrocytes, and a panel of CNS-related cell lines. IgM binding to a primitive neuro-ectodermal tumo...

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Identifiers and source

Literature Corpus work
9711e6d0-8b38-5f0d-979e-8df6c5265f15
DOI
10.1101/2023.09.29.560121
Open publication

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Cell-binding IgM in CSF is distinctive of multiple sclerosis and targets the iron transporter SCARA5DOI 10.1101/2023.09.29.560121
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