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Article

Mass Cytometry of CSF Identifies an MS-Associated B-cell Population.

Neurology(R) neuroimmunology & neuroinflammation - 1 Mar 2021

Johansson David, Rauld Céline, Roux Julien, Regairaz Camille, Galli Edoardo, Callegari Ilaria, Raad Layla, Waldt Annick, Cuttat Rachel, Roma Guglielmo, Diebold Martin, Becher Burkhard, Kuhle Jens, Derfuss Tobias, Carballido José M, Sanderson Nicholas S R

Abstract excerpt

OBJECTIVE: To identify an MS-specific immune cell population by deep immune phenotyping and relate it to soluble signaling molecules in CSF. METHODS: We analyzed surface expression of 22 markers in paired blood/CSF samples from 39 patients using mass cytometry (cytometry by time of flight). We also measured the concentrations of 296 signaling molecules in CSF using proximity extension assay. Results were analyzed...

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Identifiers

PMID: 33589541
DOI: 10.1212/NXI.0000000000000943
PMCID: PMC8057060

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