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Understanding IgM Structure and Biology to Engineer New Antibody Therapeutics

16 Apr 2025

Abstract excerpt

Immunoglobulin M (IgM) antibodies are an essential and conserved part of adaptive immunity. IgMs assemble into pentamers and hexamers that bind to antigens with high avidity. Pentamers incorporate a small protein called J-chain (JC) that is important for their transcytosis via the poly-immunoglobulin receptor (pIgR). IgM antibodies can efficiently activate complement and interact with different Fc receptors...

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PMID: 40237925
DOI: 10.1007/s40259-025-00720-6

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