Article

Turncoat antibodies unmasked in a model of autoimmune demyelination: from biology to therapy

2024-12-06

Abstract excerpt

Autoantibodies contribute to many autoimmune diseases, yet there is no approved therapy to neutralize them selectively. A popular mouse model, experimental autoimmune encephalomyelitis (EAE), could serve to develop such a therapy, provided we can better understand the nature and importance of the autoantibodies involved. Here we report the discovery of autoantibody-secreting extrafollicular plasmablasts in EAE ind...

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Literature Corpus work: 91bd54d6-4833-5192-b103-6f011ff13591
DOI: 10.1101/2024.12.03.623846

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