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Article

Autoantibody pathogenicity in a multifocal motor neuropathy induced pluripotent stem cell–derived model

1 May 2016

Abstract excerpt

OBJECTIVE: We investigated the pathogenicity of immunoglobulin M (IgM) anti-GM1 antibodies in serum from patients with multifocal motor neuropathy (MMN) using human induced pluripotent stem cell (iPSC)-derived motor neurons (MNs). METHODS: iPSCs were generated from fibroblasts and differentiated into MNs. We studied the binding of IgM to MNs, their complement-activating properties, and effects on structural...

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PMID: 27130524
DOI: 10.1002/ana.24680

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