Article

IgG Propels Atherosclerosis by Noncanonically Activating Macrophages

2026-03-17

Abstract excerpt

<h4>ABSTRACT</h4> Despite being a central component of adaptive immunity and a highly abundant serum protein, the contribution of IgG to the milieu of atherosclerosis remains unappreciated. Here, we identify a pro-atherogenic role for IgG as it activates an innate immune cascade, independent of its classical antigen-neutralizing function. Analyses of human coronary artery plaques reveal a positive correlation bet...

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Literature Corpus work: 7ad56f13-c814-5f78-bf42-34f540c9337f
DOI: 10.64898/2026.03.13.711718

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