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Emerging Functions of Natural IgM and Its Fc Receptor FCMR in Immune Homeostasis

15 Mar 2016

Abstract excerpt

Most natural IgM antibodies are encoded by germline Ig sequences and are produced in large quantities by both mice and humans in the absence of intentional immunization. Natural IgM are reactive with many conserved epitopes, including those shared by microorganisms and autoantigens. As a result, these antibodies play important roles in clearing intruding pathogens, as well as apoptotic/necrotic cells and...

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PMID: 27014278
DOI: 10.3389/fimmu.2016.00099

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