Article
Genetic variants are major determinants of CSF antibody levels in multiple sclerosis.
Brain : a journal of neurology - 1 Mar 2015
Goris An, Pauwels Ine, Gustavsen Marte W, van Son Brechtje, Hilven Kelly, Bos Steffan D, Celius Elisabeth Gulowsen, Berg-Hansen Pål, Aarseth Jan, Myhr Kjell-Morten, D'Alfonso Sandra, Barizzone Nadia, Leone Maurizio A, Martinelli Boneschi Filippo, Sorosina Melissa, Liberatore Giuseppe, Kockum Ingrid, Olsson Tomas, Hillert Jan, Alfredsson Lars, Bedri Sahl Khalid, Hemmer Bernhard, Buck Dorothea, Berthele Achim, Knier Benjamin, Biberacher Viola, van Pesch Vincent, Sindic Christian, Bang Oturai Annette, Søndergaard Helle Bach, Sellebjerg Finn, Jensen Poul Erik H, Comabella Manuel, Montalban Xavier, Pérez-Boza Jennifer, Malhotra Sunny, Lechner-Scott Jeannette, Broadley Simon, Slee Mark, Taylor Bruce, Kermode Allan G, Gourraud Pierre-Antoine, Sawcer Stephen J, Andreassen Bettina Kullle, Dubois Bénédicte, Harbo Hanne F
Abstract excerpt
Immunological hallmarks of multiple sclerosis include the production of antibodies in the central nervous system, expressed as presence of oligoclonal bands and/or an increased immunoglobulin G index-the level of immunoglobulin G in the cerebrospinal fluid compared to serum. However, the underlying differences between oligoclonal band-positive and -negative patients with multiple sclerosis and reasons for...
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