Article

Putative target antigens of the stereotyped intrathecal B cell response in multiple sclerosis

2026-01-03

Abstract excerpt

Intrathecal antibody production is a hallmark of multiple sclerosis (MS), yet the antigenic targets of these antibodies remain elusive. Intrathecal antibody-secreting cells in MS patients characteristically produce IgG1 antibodies carrying the G1m1 allotype and preferentially use IGHV4 heavy-chain genes paired with IGKV1 or IGKV3 light chains. This stereotyped pattern points to a common antigen-driven selection pr...

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Literature Corpus work: f0600ac2-5645-50a4-8fcc-824f67d7a291
DOI: 10.64898/2026.01.03.697481

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