Article

Reconstruction of epithelial transcriptional trajectories reveals heterogeneous progression and early therapy-resistance programs in high-grade serous carcinoma precursors

2026-02-09

Abstract excerpt

<h4>Background</h4> Serous-tubal intraepithelial-carcinoma (STIC) is considered the principal precursor of tubo-ovarian high-grade serous-carcinoma (HGSC), yet its biological uniformity, progression risk and potential response to poly(ADP-ribose) polymerase-inhibitors (PARPi) remain poorly defined. <h4>Methods</h4> We performed trajectory-based transcriptomic reconstruction of Fallopian-tube epithelial regions s...

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Literature Corpus work: 96e5a393-c1ba-5c3b-8881-1f8e3dcdd3e9
DOI: 10.64898/2026.02.06.704093

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