Article

Integrated Human Transcriptomics Identifies Fallopian Tube Progenitors as Plausible Precursors of High-Grade Serous Ovarian Cancer

2025-09-30

Abstract excerpt

High-grade serous ovarian cancer (HGSOC) is the most lethal gynecologic malignancy, yet its earliest cellular precursors remain incompletely defined. Here, we integrate bulk and single-nucleus RNA sequencing of human fallopian tubes, ovaries, and primary HGSOC tumors to resolve the epithelial hierarchy of the fallopian tube and examine its relationship to malignant states. We identify a rare LGR5⁺/PGR⁺ basal popul...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 845e3327-0ce5-5c56-9146-2baba7c25eb9
DOI: 10.1101/2025.09.26.678859

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Integrated Human Transcriptomics Identifies Fallopian Tube Progenitors as Plausible Precursors of High-Grade Serous Ovarian CancerDOI 10.1101/2025.09.26.678859Read

A Rare Multipotent Peg-like Epithelial Cell is a Candidate Cell-of-Origin for High-Grade Serous Ovarian CancerSemantic proximity Read

Single-cell Transcriptomics Identifies Gene Expression Networks Driving Differentiation and Tumorigenesis in the Human Fallopian TubeSemantic proximity Read

Single-cell transcriptomics identifies gene expression networks driving differentiation and tumorigenesis in the human fallopian tubeSemantic proximity Read

Single Cell Transcriptomics identifies a WNT7A-FZD5 Signaling Axis that maintains Fallopian Tube Stem Cells in Patient-derived OrganoidsSemantic proximity Read

In vitro and in vivo correlates of physiological and neoplastic human Fallopian tube stem cellsSemantic proximity Read

WNT and inflammatory signaling distinguish human Fallopian tube epithelial cell populationsSemantic proximity Read

A Cellular atlas of the human fallopian tube reveals the metamorphosis of secretory epithelial cells during the menstrual cycle and menopauseSemantic proximity Read

Single-cell transcriptomic analysis highlights origin and pathological process of human endometrioid endometrial carcinomaSemantic proximity Read

Cellular heterogeneity of human fallopian tubes in normal and hydrosalpinx disease states identified using scRNA-seqSemantic proximity Read

A molecular atlas of the human postmenopausal fallopian tube and ovary from single-cell RNA and ATAC sequencingSemantic proximity Read

High grade serous ovarian carcinomas originate in the fallopian tube.Semantic proximity Read