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Multimodal Spatial Profiling Reveals Immune Suppression and Microenvironment Remodeling in Fallopian Tube Precursors to High-Grade Serous Ovarian Carcinoma

2024-09-27

Abstract excerpt

<h4>ABSTRACT</h4> High-Grade Serous Ovarian Cancer (HGSOC) originates from fallopian tube (FT) precursors. However, the molecular changes that occur as precancerous lesions progress to HGSOC are not well understood. To address this, we integrated high-plex imaging and spatial transcriptomics to analyze human tissue samples at different stages of HGSOC development, including p53 signatures, serous tubal intraepith...

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Literature Corpus work
ecd9959e-34ab-5846-93d1-e320e826ab8f
DOI
10.1101/2024.09.25.615007
Open publication

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Multimodal Spatial Profiling Reveals Immune Suppression and Microenvironment Remodeling in Fallopian Tube Precursors to High-Grade Serous Ovarian CarcinomaDOI 10.1101/2024.09.25.615007
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