High grade serous ovarian carcinomas originate in the fallopian tube.

doi:10.1038/s41467-017-00962-1

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Article

High grade serous ovarian carcinomas originate in the fallopian tube.

Nature communications - 23 Oct 2017

Labidi-Galy S Intidhar, Papp Eniko, Hallberg Dorothy, Niknafs Noushin, Adleff Vilmos, Noe Michael, Bhattacharya Rohit, Novak Marian, Jones Siân, Phallen Jillian, Hruban Carolyn A, Hirsch Michelle S, Lin Douglas I, Schwartz Lauren, Maire Cecile L, Tille Jean-Christophe, Bowden Michaela, Ayhan Ayse, Wood Laura D, Scharpf Robert B, Kurman Robert, Wang Tian-Li, Shih Ie-Ming, Karchin Rachel, Drapkin Ronny, Velculescu Victor E

Abstract excerpt

High-grade serous ovarian carcinoma (HGSOC) is the most frequent type of ovarian cancer and has a poor outcome. It has been proposed that fallopian tube cancers may be precursors of HGSOC but evolutionary evidence for this hypothesis has been limited. Here, we perform whole-exome sequence and copy number analyses of laser capture microdissected fallopian tube lesions (p53 signatures, serous tubal intraepithelial...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29061967
DOI: 10.1038/s41467-017-00962-1
PMCID: PMC5653668

Genes

BRCA1
BRCA2
PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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