Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Spatial Transcriptomic Analysis of Ovarian Cancer Precursors Reveals Reactivation of IGFBP2 during Pathogenesis

7 Oct 2022

Abstract excerpt

Elucidating the earliest pathogenic steps in cancer development is fundamental to improving its early detection and prevention. Ovarian high-grade serous carcinoma (HGSC), a highly aggressive cancer, mostly originates from the fallopian tube epithelium through a precursor stage, serous tubal intraepithelial carcinoma (STIC). In this study, we performed spatial transcriptomic analysis to compare STICs, carcinoma,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Growth Hormone and Insulin-like Growth Factors
Share to Ovarian cancer diagnosis and treatment
Share to Reproductive Biology and Fertility

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 36206311
DOI: 10.1158/0008-5472.can-22-1620

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Spatial Transcriptomic Analysis of Ovarian Cancer Precursors Reveals Reactivation of IGFBP2 during PathogenesisPMID 36206311Read ↗

Preneoplastic Lesions Fimbria Early Diagnosis Markers Underlying Timeline Mechanisms at The Origin of Ovarian Cancer in BRAC1/2 Patients: Case Reports Based on Proteogenomic StudySemantic proximity Read ↗

Multimodal Spatial Profiling Reveals Immune Suppression and Microenvironment Remodeling in Fallopian Tube Precursors to High-Grade Serous Ovarian CarcinomaSemantic proximity Read ↗

From fallopian tube epithelium to high-grade serous ovarian cancer: A single-cell resolution review of sex steroid hormone signalingSemantic proximity Read ↗

Rete Ovarii Epithelial Cells as an Unappreciated Cell of Origin for Pelvic and Ovarian High-Grade Serous CarcinomaSemantic proximity Read ↗

WNT and inflammatory signaling distinguish human Fallopian tube epithelial cell populationsSemantic proximity Read ↗

The tubal epigenome - An emerging target for ovarian cancer.Semantic proximity Read ↗

3D multi-omic mapping of whole nondiseased human fallopian tubes at cellular resolution reveals a large incidence of ovarian cancer precursorsSemantic proximity Read ↗

Integration of cell-type resolved spatial proteomics and transcriptomics reveals novel mechanisms in early ovarian cancerSemantic proximity Read ↗

High grade serous ovarian carcinomas originate in the fallopian tube.Semantic proximity Read ↗

In vitro and in vivo correlates of physiological and neoplastic human Fallopian tube stem cellsSemantic proximity Read ↗

Integrative analysis reveals early epigenetic alterations in high-grade serous ovarian carcinomasSemantic proximity Read ↗

Aged and BRCA -Mutated Stromal Cells Drive Epithelial Cell TransformationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.