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Article

Genomic landscape and evolutionary trajectories of ovarian cancer precursor lesions.

The Journal of pathology - 1 May 2019

Wu Ren-Chin, Wang Pei, Lin Shiou-Fu, Zhang Ming, Song Qianqian, Chu Tiffany, Wang Brant G, Kurman Robert J, Vang Russell, Kinzler Kenneth, Tomasetti Cristian, Jiao Yuchen, Shih Ie-Ming, Wang Tian-Li

Abstract excerpt

The clonal relationship between ovarian high-grade serous carcinoma (HGSC) and its presumed precursor lesion, serous tubal intraepithelial carcinoma (STIC), has been reported. However, when analyzing patients with concurrent ovarian carcinoma and tubal lesion, the extensive carcinoma tissues present at diagnosis may have effaced the natural habitat of precursor clone(s), obscuring tumor clonal evolutionary...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Carcinoma, Ovarian Epithelial

Share to Cystadenocarcinoma, Serous

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Share to Fallopian Tube Neoplasms

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Source

Open in PubMed Open full text

Identifiers

PMID: 30560554
DOI: 10.1002/path.5219
PMCID: PMC6618168

Genes

TP53
STIL

Provenance

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