Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The genomic trajectory of ovarian high-grade serous carcinoma can be observed in STIC lesions.

The Journal of pathology - 1 Sept 2024

Cheng Zhao, Ennis Darren P, Lu Bingxin, Mirza Hasan B, Sokota Chishimba, Kaur Baljeet, Singh Naveena, Le Saux Olivia, Russo Giorgia, Giannone Gaia, Tookman Laura A, Krell Jonathan, Barnes Chris, McDermott Jackie, McNeish Iain A

Abstract excerpt

Ovarian high-grade serous carcinoma (HGSC) originates in the fallopian tube, with secretory cells carrying a TP53 mutation, known as p53 signatures, identified as potential precursors. p53 signatures evolve into serous tubal intraepithelial carcinoma (STIC) lesions, which in turn progress into invasive HGSC, which readily spreads to the ovary and disseminates around the peritoneal cavity. We recently investigated...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carcinoma in Situ
Share to Cystadenocarcinoma, Serous

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Copy Number Variations

Share to Fallopian Tube Neoplasms

Share to Neoplasm Grading

Share to Ovarian Neoplasms

Share to Ploidies

Share to Whole Genome Sequencing

Source

Identifiers

PMID: 38956451
DOI: 10.1002/path.6322

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The genomic trajectory of ovarian high-grade serous carcinoma can be observed in STIC lesions.PMID 38956451Read ↗

The genomic trajectory of ovarian high grade serous carcinoma is determined in STIC lesionsSemantic proximity Read ↗

High grade serous ovarian carcinomas originate in the fallopian tube.Semantic proximity Read ↗

Genomic landscape and evolutionary trajectories of ovarian cancer precursor lesions.Semantic proximity Read ↗

Genomic analysis of low-grade serous ovarian carcinoma to identify key drivers and therapeutic vulnerabilities.Semantic proximity Read ↗

Distinct evolutionary trajectories of primary high-grade serous ovarian cancers revealed through spatial mutational profiling.Semantic proximity Read ↗

Reconstruction of epithelial transcriptional trajectories reveals heterogeneous progression and early therapy-resistance programs in high-grade serous carcinoma precursorsSemantic proximity Read ↗

Evidence for lineage continuity between early serous proliferations (ESPs) in the Fallopian tube and disseminated high-grade serous carcinomas.Semantic proximity Read ↗

Evolutionary states and trajectories characterized by distinct pathways stratify ovarian high-grade serous carcinoma patientsSemantic proximity Read ↗

Aneuploidy Landscape in Precursors of Ovarian CancerSemantic proximity Read ↗

The genomic landscape of early stage ovarian high grade serous carcinomaSemantic proximity Read ↗

Next-Generation Sequencing of Tubal Intraepithelial Carcinomas.Semantic proximity Read ↗

Multi-omic analysis of subtype evolution and heterogeneity in high-grade serous ovarian carcinomaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.