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Single-Cell Transcriptome Analysis Reveals IRF1-Driven Epithelial States and Glycosaminoglycan–Glycolysis Coupling in Cisplatin-Resistant HGSOC

1 Aug 2026

Abstract excerpt

Objectives: Cisplatin resistance is the principal cause of relapse in high-grade serous ovarian cancer (HGSOC), but bulk-expression signatures cannot localize resistant malignant states or the tumor-microenvironment (TME) interactions that sustain them. This study aimed to define cisplatin-resistant epithelial cell states and their regulatory and metabolic circuits by integrating multi-cohort single-cell...

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PMID: 42605287
DOI: 10.1177/11769351261478408

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