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Clinical significance of T cell metabolic reprogramming in cancer

10 Aug 2016

Abstract excerpt

Conversion of normal cells to cancer is accompanied with changes in their metabolism. During this conversion, cell metabolism undergoes a shift from oxidative phosphorylation to aerobic glycolysis, also known as Warburg effect, which is a hallmark for cancer cell metabolism. In cancer cells, glycolysis functions in parallel with the TCA cycle and other metabolic pathways to enhance biosynthetic processes and thus...

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PMID: 27510264
DOI: 10.1186/s40169-016-0110-9

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