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Article

APOE Genotype and Alzheimer Disease Risk Across Age, Sex, and Population Ancestry.

JAMA neurology - 1 Dec 2023

Belloy Michael E, Andrews Shea J, Le Guen Yann, Cuccaro Michael, Farrer Lindsay A, Napolioni Valerio, Greicius Michael D

Abstract excerpt

Importance: Apolipoprotein E (APOE)*2 and APOE*4 are, respectively, the strongest protective and risk-increasing, common genetic variants for late-onset Alzheimer disease (AD), making APOE status highly relevant toward clinical trial design and AD research broadly. The associations of APOE genotypes with AD are modulated by age, sex, race and ethnicity, and ancestry, but these associations remain unclear,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 37930705
DOI: 10.1001/jamaneurol.2023.3599
PMCID: PMC10628838

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