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Article

Circular DNA in the human germline and its association with recombination.

Molecular cell - 6 Jan 2022

Henriksen Rasmus Amund, Jenjaroenpun Piroon, Sjøstrøm Ida Borup, Jensen Kristian Reveles, Prada-Luengo Iñigo, Wongsurawat Thidathip, Nookaew Intawat, Regenberg Birgitte

Abstract excerpt

Extrachromosomal circular DNA (eccDNA) is common in somatic tissue, but its existence and effects in the human germline are unexplored. We used microscopy, long-read DNA sequencing, and new analytic methods to document thousands of eccDNAs from human sperm. EccDNAs derived from all genomic regions and mostly contained a single DNA fragment, although some consisted of multiple fragments. The generation of eccDNA...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 34951964
DOI: 10.1016/j.molcel.2021.11.027
PMCID: PMC10707452

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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