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What Is Extrachromosomal Circular DNA and What Does It Do?

2 Apr 2020

Abstract excerpt

It is known that DNA in the cell nucleus is packed in the form of linear chromosomes. For many years, researchers have observed smaller lengths of DNA alongside the chromosomes that are organized in circular forms. Some of these particles, which have been referred to as extrachromosomal circular DNA (eccDNAs) or microDNAs, are typically small (<1 kb), gene-sparse, and non-amplified. Total eccDNA abundance in...

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PMID: 32470125
DOI: 10.1093/clinchem/hvaa096

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