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Novel and diverse functions of the DNA mismatch repair family in mammalian meiosis and recombination

1 Jan 2004

Abstract excerpt

The mismatch repair (MMR) family is a highly conserved group of proteins that function in genome stabilization and mutation avoidance. Their role has been particularly well studied in the context of DNA repair following replication errors, and disruption of these processes results in characteristic microsatellite instability, repair defects and, in mammals, susceptibility to cancer. An additional role in meiotic...

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PMID: 15467367
DOI: 10.1159/000080600

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