Article

A <i>Recql5</i> mutant enables complex chromosomal engineering of mouse zygotes

2023-04-06

Abstract excerpt

<h4>Summary</h4> Complex chromosomal rearrangements (CCRs) are often observed in clinical samples from patients with cancer and congenital diseases but are difficult to induce experimentally. For generating animal models, these CCRs must be induced as desired, otherwise they cause profound genome instability and/or result in cell death. Here, we report the first success in establishing animal models for CCRs. The...

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Literature Corpus work: d1423409-fc7d-5084-97d3-df3d4977017d
DOI: 10.1101/2023.04.06.535871

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