Article

MRE11 suppresses germline mutagenesis at meiotic double-strand breaks in mice

2026-02-12

Abstract excerpt

SPO11 forms hundreds of double-strand breaks (DSBs) to initiate meiotic recombination that is normally error-free. However, SPO11 activity can be mutagenic when one chromatid incurs closely spaced DSBs (double cuts), especially when DSBs are dysregulated by loss of the ATM kinase. De novo indels and structural variants can arise via end joining at double cuts within a single hotspot (microdeletions) or at adjacen...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 85646f5c-1f4f-576f-b19a-835fbb9cbdac
DOI: 10.64898/2026.02.11.705388

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

MRE11 suppresses germline mutagenesis at meiotic double-strand breaks in miceDOI 10.64898/2026.02.11.705388Read

De novo deletions and duplications at recombination hotspots in mouse germlines.Semantic proximity Read

De novo deletions and duplications at recombination hotspots in mouse germlinesSemantic proximity Read

Homologous recombinational repair proteins in mouse meiosisSemantic proximity Read

A Rad50-null mutation in mouse germ cells causes reduced DSB formation, abnormal DSB end resection and complete loss of germ cells.Semantic proximity Read

Meiotic DNA breaks drive multifaceted mutagenesis in the human germ line.Semantic proximity Read

In vitro reconstitution of meiotic DNA double-strand-break formationSemantic proximity Read

The multiple roles of the Mre11 complex for meiotic recombination.Semantic proximity Read

A pathway for error-free non-homologous end joining of resected meiotic double-strand breaks.Semantic proximity Read

A genome-wide atlas of meiotic recombination intermediates reveals distinct modes of DNA repair that direct crossovers away from transcriptionally marked genesSemantic proximity Read

Numerical and spatial patterning of yeast meiotic DNA breaks by Tel1.Semantic proximity Read

Association of Mre11p with double-strand break sites during yeast meiosis.Semantic proximity Read

Locally, meiotic double-strand breaks targeted by Gal4BD-Spo11 occur at discrete sites with a sequence preference.Semantic proximity Read