Article
De novo deletions and duplications at recombination hotspots in mouse germlines.
Cell - 24 Nov 2021
Lukaszewicz Agnieszka, Lange Julian, Keeney Scott, Jasin Maria
Abstract excerpt
Numerous DNA double-strand breaks (DSBs) arise during meiosis to initiate homologous recombination. These DSBs are usually repaired faithfully, but here, we uncover a distinct type of mutational event in which deletions form via joining of ends from two closely spaced DSBs (double cuts) within a single hotspot or at adjacent hotspots on the same or different chromatids. Deletions occur in normal meiosis but are...
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