Article
DNA recombination. Recombination initiation maps of individual human genomes.
Science (New York, N.Y.) - 14 Nov 2014
Pratto Florencia, Brick Kevin, Khil Pavel, Smagulova Fatima, Petukhova Galina V, Camerini-Otero R Daniel
Abstract excerpt
DNA double-strand breaks (DSBs) are introduced in meiosis to initiate recombination and generate crossovers, the reciprocal exchanges of genetic material between parental chromosomes. Here, we present high-resolution maps of meiotic DSBs in individual human genomes. Comparing DSB maps between individuals shows that along with DNA binding by PRDM9, additional factors may dictate the efficiency of DSB formation. We...
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