Article

BrainBeacon: A Cross-Species Foundation Model for Single-cell Resolved Brain Spatial Transcriptomics

2025-07-10

Abstract excerpt

The brain’s functional complexity emerges from spatiotemporal heterogeneity in molecular, cellular, and circuit organization, shaped by evolution, aging, and disease. Single-cell spatial transcriptomics provides a transformative framework to decode this complexity, resolving cell-type-specific expression patterns, region-specific regulation, evolutionary divergence, and disease-associated disruptions. Despite rece...

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Literature Corpus work: f006244d-921d-5f0f-a14f-d4b8e8cc07af
DOI: 10.1101/2025.07.08.663729

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