Article

Loss of E-cadherin enhances IGF1-IGF1R pathway activation and sensitizes breast cancers to anti-IGF1R inhibitors

2018-01-24

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Purpose</h4> Insulin-like growth factor I (IGF1) signaling regulates breast cancer initiation and progression and associated cancer phenotypes. We previously identified E-cadherin (CDH1) as a repressor of IGF1 signaling and in this study examined how loss of E-cadherin affects IGF1R signaling and response to anti-IGF1R therapies in breast cancer. <h4>Experimental Design</h4> Breast cance...

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Literature Corpus work: 752252f6-ce35-54f0-b729-f0fa5dad512e
DOI: 10.1101/253278

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