Article
Integration of genomic, transcriptomic and proteomic data identifies two biologically distinct subtypes of invasive lobular breast cancer.
Scientific reports - 5 Jan 2016
Michaut Magali, Chin Suet-Feung, Majewski Ian, Severson Tesa M, Bismeijer Tycho, de Koning Leanne, Peeters Justine K, Schouten Philip C, Rueda Oscar M, Bosma Astrid J, Tarrant Finbarr, Fan Yue, He Beilei, Xue Zheng, Mittempergher Lorenza, Kluin Roelof J C, Heijmans Jeroen, Snel Mireille, Pereira Bernard, Schlicker Andreas, Provenzano Elena, Ali Hamid Raza, Gaber Alexander, O'Hurley Gillian, Lehn Sophie, Muris Jettie J F, Wesseling Jelle, Kay Elaine, Sammut Stephen John, Bardwell Helen A, Barbet Aurélie S, Bard Floriane, Lecerf Caroline, O'Connor Darran P, Vis Daniël J, Benes Cyril H, McDermott Ultan, Garnett Mathew J, Simon Iris M, Jirström Karin, Dubois Thierry, Linn Sabine C, Gallagher William M, Wessels Lodewyk F A, Caldas Carlos, Bernards Rene
Abstract excerpt
Invasive lobular carcinoma (ILC) is the second most frequently occurring histological breast cancer subtype after invasive ductal carcinoma (IDC), accounting for around 10% of all breast cancers. The molecular processes that drive the development of ILC are still largely unknown. We have performed a comprehensive genomic, transcriptomic and proteomic analysis of a large ILC patient cohort and present here an...
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