Article

Restoration of E-cadherin Expression Alters Metastatic Organotropism in Invasive Lobular Breast Carcinoma Models

2026-05-18

Abstract excerpt

Invasive lobular carcinoma (ILC) is the most frequently diagnosed special histological subtype of invasive breast cancer and accounts for 10 – 15% of all cases. The pathognomonic hallmark of ILC is the genetic loss of E-cadherin ( CDH1 ) causing the disruption of adherens junctions and resulting in discohesive, linear growth. To better understand the role of E-cadherin in ILC metastasis, we generated three ILC ce...

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Literature Corpus work: b0f7f2c7-9c12-5ca2-af34-cd761a61ee0a
DOI: 10.64898/2026.05.14.724680

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