Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

NKT cells adopt a glutamine-addicted phenotype to regulate their homeostasis and function.

Cell reports - 25 Oct 2022

Kumar Ajay, Yarosz Emily L, Andren Anthony, Zhang Li, Lyssiotis Costas A, Chang Cheong-Hee

Abstract excerpt

Natural killer T (NKT) cells operate distinctly different metabolic programming from CD4 T cells, including a strict requirement for glutamine to regulate cell homeostasis. However, the underlying mechanisms remain unknown. Here, we report that at a steady state, NKT cells have higher glutamine levels than CD4 T cells and that NKT cells increase glutaminolysis on activation. Activated NKT cells use glutamine to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to AMP-Activated Protein Kinases
Share to Glutamine

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Glutathione

Share to Interleukin-4

Share to Mechanistic Target of Rapamycin Complex 1

Share to Natural Killer T-Cells

Share to Nitrogen

Share to TOR Serine-Threonine Kinases

Source

Open in PubMed Open full text

Identifiers

PMID: 36288696
DOI: 10.1016/j.celrep.2022.111516
PMCID: PMC9664378

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

NKT cells adopt a glutamine-addicted phenotype to regulate their homeostasis and function.PMID 36288696Read ↗

Cellular metabolism regulates the differentiation and function of T-cell subsetsSemantic proximity Read ↗

Distinct bioenergetic features of human invariant natural killer T (iNKT) cells enable retained functions in nutrient-deprived statesSemantic proximity Read ↗

Unbalanced Glutamine Partitioning between CD8T Cells and Cancer Cells Accompanied by Immune Cell Dysfunction in Hepatocellular CarcinomaSemantic proximity Read ↗

Bcl-2 protein Noxa is required for metabolic reprogramming to glutamine dependence and for apoptosis in stimulated human CD8 <sup>+</sup> T cellsSemantic proximity Read ↗

Metabolic Program of Regulatory B Lymphocytes and Influence in the Control of Malignant and Autoimmune Situations.Semantic proximity Read ↗

Metabolic features of innate lymphoid cellsSemantic proximity Read ↗

Metabolic T-cell phenotypes: from bioenergetics to function.Semantic proximity Read ↗

Metabolic reprogramming in cancer: unraveling the role of glutamine in tumorigenesis.Semantic proximity Read ↗

The expanding Pandora’s toolbox of CD8+T cell: from transcriptional control to metabolic firingSemantic proximity Read ↗

Biphasic response of CD8 T cell to asparagine restriction maximizes its metabolic fitness and antitumoral functionalitySemantic proximity Read ↗

Synthetic auxotrophy reveals metabolic regulation of plasma cell generation, affinity maturation, and cytokine receptor signalingSemantic proximity Read ↗

A metabolic synthetic lethality of phosphoinositide 3-kinase-driven cancerSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.