NKT cells adopt a glutamine-addicted phenotype to regulate their homeostasis and function.

doi:10.1016/j.celrep.2022.111516

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Article

NKT cells adopt a glutamine-addicted phenotype to regulate their homeostasis and function.

Cell reports - 25 Oct 2022

Kumar Ajay, Yarosz Emily L, Andren Anthony, Zhang Li, Lyssiotis Costas A, Chang Cheong-Hee

Abstract excerpt

Natural killer T (NKT) cells operate distinctly different metabolic programming from CD4 T cells, including a strict requirement for glutamine to regulate cell homeostasis. However, the underlying mechanisms remain unknown. Here, we report that at a steady state, NKT cells have higher glutamine levels than CD4 T cells and that NKT cells increase glutaminolysis on activation. Activated NKT cells use glutamine to...

Topics

Natural Killer T-Cells
Interleukin-4
Glutamine
AMP-Activated Protein Kinases
Interferon-gamma
Homeostasis
Hexosamines
Phenotype
TOR Serine-Threonine Kinases
Mechanistic Target of Rapamycin Complex 1
Nitrogen
Glutathione

Source

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Identifiers

PMID: 36288696
DOI: 10.1016/j.celrep.2022.111516
PMCID: PMC9664378

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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