Article

Hepatic WDR23 proteostasis mediates insulin clearance by regulating insulin-degrading enzyme

2022-11-25

Abstract excerpt

<h4>ABSTRACT</h4> Clearance of circulating insulin is critical for metabolic homeostasis. In the liver, insulin is degraded by the activity of the insulin-degrading enzyme (IDE). Here we establish a hepatic regulatory axis for IDE through WDR23-proteostasis. Wdr23KO mice have increased IDE expression, reduced circulating insulin, and defective insulin responses. Genetically engineered human cell models lacking...

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Literature Corpus work: 95a5da78-1e54-56d5-b11d-6eacff5b5eea
DOI: 10.1101/2022.11.24.516014

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