Article

The essential roles of FXR in diet and age influenced metabolic changes and liver disease development: a multi-omics study

2022-12-08

Abstract excerpt

<h4>Background: </h4> Aging and diet are risks for metabolic diseases. Bile acid receptor farnesoid X receptor (FXR) knockout (KO) mice develop metabolic liver diseases that progress into cancer as they age, which is accelerated by Western diet (WD) intake. The current study uncovers the molecular signatures for diet and age-linked metabolic liver disease development in an FXR-dependent manner. Methods Wild-type...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: d9f36107-008a-593b-89df-e4be78d65fbd
DOI: 10.21203/rs.3.rs-2336231/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

The essential roles of FXR in diet and age influenced metabolic changes and liver disease development: a multi-omics studyDOI 10.21203/rs.3.rs-2336231/v1Read

Machine Learning to Identify Molecular Markers for Metabolic Disease Development Using Mouse ModelsSemantic proximity Read

Gender Differences in Bile Acids and Microbiota in Relationship with Gender Dissimilarity in Steatosis Induced by Diet and FXR Inactivation.Semantic proximity Read

Microbiota metabolized Bile Acids accelerate Gastroesophageal Adenocarcinoma via FXR inhibitionSemantic proximity Read

Global molecular landscape of early MASLD progression in obesitySemantic proximity Read

PPARα-ERRα crosstalk mitigates metabolic dysfunction-associated steatotic liver disease progressionSemantic proximity Read

Unraveling MASLD Through the Use of Omics TechnologiesSemantic proximity Read

Orchestration of Gut–Liver-Associated Transcription Factors in MAFLD: From Cross-Organ Interactions to Therapeutic InnovationSemantic proximity Read

A new dietary rat model fully recapitulates metabolic dysfunction-associated steatotic liver disease pathophysiology and mimics human disease with advanced liver fibrosis and portal hypertensionSemantic proximity Read

Sex differences in bile acid homeostasis and excretion underlie the disparity in liver cancer incidence between males and femalesSemantic proximity Read

The Transcriptomic Signature Of Disease Development And Progression Of Nonalcoholic Fatty Liver DiseaseSemantic proximity Read

E2F2 transcription factor promotes a cholestatic MASH phenotype by regulating hepatobiliary metabolism through miR-34a-5p.Semantic proximity Read

Longitudinal analysis of a dietary mouse model of non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH)Semantic proximity Read