Article

WDR23 mediates NRF2 proteostasis and cytoprotective capacity in the hippocampus

2023-10-11

Abstract excerpt

<h4>ABSTRACT</h4> Pathogenic brain aging and neurodegenerative diseases such as Alzheimer’s disease and Parkinson’s disease are characterized by chronic neuroinflammation and the accumulation of dysfunctional or misfolded proteins that lead to progressive neuronal cell death. Here we demonstrate that a murine model with global loss of the CUL4-DDB1 substrate receptor WDR23 ( Wdr23KO ) results in changes in multi...

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Literature Corpus work: 52a457d6-e492-56ab-a7b0-e154ab308d65
DOI: 10.1101/2023.10.10.561805

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