Article

Creld2 function during unfolded protein response is essential for liver metabolism homeostasis

2020-01-29

Abstract excerpt

The unfolded protein response (UPR) is associated with the hepatic metabolic function, yet it is not well understood how endoplasmic reticulum (ER) disturbance might influence metabolic homeostasis. Here, we describe the physiological function of Cysteine-rich with EGF-like domains 2 (Creld2), previously characterized as a downstream target of the ER-stress signal transducer Atf6. To this end we generated Creld2...

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Literature Corpus work: a31123ff-88fe-560e-beb9-c99bd28eae6d
DOI: 10.1101/2020.01.28.923136

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