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Article

Liver Med23 ablation improves glucose and lipid metabolism through modulating FOXO1 activity

16 Sept 2014

Abstract excerpt

Mediator complex is a molecular hub integrating signaling, transcription factors, and RNA polymerase II (RNAPII) machinery. Mediator MED23 is involved in adipogenesis and smooth muscle cell differentiation, suggesting its role in energy homeostasis. Here, through the generation and analysis of a liver-specific Med23-knockout mouse, we found that liver Med23 deletion improved glucose and lipid metabolism, as well...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 25223702
DOI: 10.1038/cr.2014.120

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