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Article

Proteomic analysis of mitochondria in APOE transgenic mice and in response to an ischemic challenge.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism - 1 Jan 2012

James Rachel, Searcy James L, Le Bihan Thierry, Martin Sarah F, Gliddon Catherine M, Povey Joanne, Deighton Ruth F, Kerr Lorraine E, McCulloch James, Horsburgh Karen

Abstract excerpt

Apolipoprotein E (APOE)-ɛ4 is associated with a deleterious outcome after ischemic brain injury, which may involve abnormal regulation of mitochondrial function. We have assessed the mitochondrial proteomic response of APOE-ɛ3 and APOE-ɛ4 transgenic mice to transient global ischemic injury in the hippocampus. A genotype-dependent increase in ApoE levels in mitochondria was observed after ischemia, with APOE-ɛ4...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 21878944
DOI: 10.1038/jcbfm.2011.120
PMCID: PMC3323298

Genes

APOE
ETFA
GLUL
IARS2
NDUFA11
NDUFS3
OXR1
PHYHIPL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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