Article

Per-allele disease and complex trait effect sizes are predominantly African MAF-dependent in European populations

2026-01-02

Abstract excerpt

Understanding genetic architectures of disease is fundamental to partitioning heritability, polygenic risk prediction, and statistical fine-mapping. Genetic architectures of disease in European populations have been shown to depend on European minor allele frequency (MAF): SNPs with lower MAF have larger per-allele effects, due to the action of negative selection. However, we hypothesized that African MAF (defined...

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Literature Corpus work: c288cbd1-92ef-55cc-8397-857090342375
DOI: 10.64898/2025.12.31.25343290

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