Simple scaling laws control the genetic architectures of human complex traits.

Abstract excerpt

Genome-wide association studies have revealed that the genetic architectures of complex traits vary widely, including in terms of the numbers, effect sizes, and allele frequencies of significant hits. However, at present we lack a principled way of understanding the similarities and differences among traits. Here, we describe a probabilistic model that combines the effects of mutation, drift, and stabilizing...

Topics

• Humans
• Multifactorial Inheritance
• Models, Genetic
• Genome-Wide Association Study
• Mutation
• Selection, Genetic