Article

Polygenicity of complex traits is explained by negative selection

2018-09-18

Abstract excerpt

Complex traits and common disease are highly polygenic: thousands of common variants are causal, and their effect sizes are almost always small. Polygenicity could be explained by negative selection, which constrains common-variant effect sizes and may reshape their distribution across the genome. We refer to this phenomenon as flattening , as genetic signal is flattened relative to the underlying biology. We int...

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Literature Corpus work: 1c89f42d-9159-5164-bbb0-19daa8bf3943
DOI: 10.1101/420497

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