Article

Rare variants drive high variance in human ancestral fitness at mutation-selection-drift balance

2026-07-31

Abstract excerpt

It is an open question whether variation in the genetic load of unconditionally deleterious mutations contributes substantially to the variability in human disease. Here, we solve for mutation-selection-drift balance and predict variation in genetic load given a realistic human genome-wide deleterious mutation rate, U , and a distribution of fitness effects (DFE). Empirical estimates of U come from sequence cons...

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Literature Corpus work: 50fd1602-17e8-5fa2-bc8f-dd7d1109b5e3
DOI: 10.64898/2026.07.29.741368

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