Article

Probing the aggregated effects of purifying selection per individual on 1,380 medical phenotypes in the UK biobank

2020-11-18

Abstract excerpt

Understanding the relationship between natural selection and phenotypic variation has been a long-standing challenge in human population genetics. With the emergence of biobank-scale datasets, along with new statistical metrics to approximate strength of purifying selection at the variant level, it is now possible to correlate a proxy of individual relative fitness with a range of medical phenotypes. We calculated...

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Literature Corpus work: 28daf06e-44cd-5e98-9562-4bfe0016896d
DOI: 10.1101/2020.11.16.385724

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