Article

Inference of the distribution of selection coefficients for new nonsynonymous mutations using large samples

2016-08-25

Abstract excerpt

<h4>ABSTRACT</h4> The distribution of fitness effects (DFE) has considerable importance in population genetics. To date, estimates of the DFE come from studies using a small number of individuals. Thus, estimates of the proportion of moderately to strongly deleterious new mutations may be unreliable because such variants are unlikely to be segregating in the data. Additionally, the true functional form of the DFE...

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Literature Corpus work: 87b674ff-0caa-536e-bd52-2bf98e0ff751
DOI: 10.1101/071431

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