Article

Selection and explosive growth may hamper the performance of rare variant association tests

2015-03-02

Abstract excerpt

Much recent debate has focused on the role of rare variants in complex phenotypes. However, it is well known that rare alleles can only contribute a substantial proportion of the phenotypic variance when they have much larger effect sizes than common variants, which is most easily explained by natural selection constraining trait-altering alleles to low frequency. It is also plausible that demographic events will...

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Literature Corpus work: 96995762-75f1-5333-8258-e4c229ccfcfc
DOI: 10.1101/015917

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